The Effect of Celecoxib on Kidney Function in Elderly People
Abstract
Nonsteroidal anti-inflammatory drugs, or NSAIDs, are typically prescribed to relieve inflammation and pain. The first two selective cyclo-oxygenase-2 (COX-2) inhibitors were approved for commercialization by the US Food and Drug Administration (FDA) in December 1998 and May 1999, respectively. Part of the reason coxibs, or selective COX-2 inhibitors, were developed was the expectation that they would be less harmful than conventional NSAIDs. The potential harm that conventional NSAID use may cause to the kidneys is widely recognized. There is a remote possibility of serious kidney toxicity, nevertheless.
Aim: The purpose of this study is to evaluate how celecoxib affects renal function in the elderly.
Conclusion: As the primary treatment for pain and fever, NSAIDs decrease the inflammatory response triggered by COX enzymes, exposing individuals to dangerous and detrimental adverse consequences on the kidney.
Recommendations: Physicians should be informed that patients with normal or impaired renal function have been linked to substantial or potentially fatal renal failure while using celecoxib for a short period of time. Celecoxib should not be taken by patients who have severe renal disease.
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