Exploring the Role of Gut Microbiota Modulation in Enhancing Oral Bioavailability of Poorly Soluble Drugs

  • Helal Ahmed Alomar et al.
Keywords: Gut microbiota, Oral bioavailability, poorly soluble drugs, probiotics, prebiotics, symbiotic, Drug absorption

Abstract

To investigate the effect of gut microbiota modulation at a target location on oral bioavailability of poorly soluble drugs using probiotics, prebiotics, and synbiotic therapy. A double-blind, randomized, placebo-controlled study was conducted in 120 healthy volunteers who were divided into four intervention groups: control, probiotic (Lactobacillus rhamnosus GG and Bifidobacterium longum), prebiotic (inulin and fructooligosaccharides), and synbiotic therapy. Participants received a standardized dose of three poorly soluble model drugs (simvastatin, curcumin, and quercetin) before and after 28 days of intervention. Plasma drug levels, gut microbiota composition (16S rRNA sequencing), and microbial metabolites were measured.

Author Biography

Helal Ahmed Alomar et al.

Helal Ahmed Alomar1, Bander Saleh Bafakeer2, Abdullah Masoud Alsaedi 3, Khalid Hussin Barbari4, Salah Mohammed Alghamdi5, Alhumaidi Hamad Alharbi6, Ismail Hamed Altayyar7, Abdulaziz Saleem Alsubhi8, Yasir Salem Saeed Alfaidi9, Fawaz Salih Alzahrani10, Sultan Awadh Alzeyadi11, Mohammed Fahad Allhyani12
1Pharmacist II, Pharmaceutical Care Department, King Abdulaziz Medical City, Ministry of National Guard, Jeddah, Saudi Arabia
2Pharmacy Technician III, Pharmaceutical Care Department, King Abdulaziz, Medical City Ministry of National Guard, Jeddah, Saudi Arabia
3Pharmacy Technicianm III, Pharmaceutical Care Department, King Abdulaziz Medical City Ministry of National Guard, Jeddah, Saudi Arabia
4Pharmacy Technician lll, Pharmaceutical Care Department, King Abdulaziz, Medical City, Ministry of National Guard, Jeddah, Saudi Arabia
5Pharmacy Technician ll, Pharmaceutical Care Department, Dialysis, King Abdulaziz Medical City Ministry of National Guard, Mecca, Saudi Arabia
6Pharmacy technician III, Pharmaceutical Care Department, King Abdulaziz Medical City Ministry of National Guard, Jeddah, Saudi Arabia
7Pharmacy Techniclnic lll, Pharmaceutical Care Department, King Abdulaziz Medical City Ministry of National Guard, Jeddah, Saudi Arabia
8Pharmacy Technician lll, Pharmaceutical Care Department, King Abdulaziz Medical City Ministry of National Guard, Jeddah, Saudi Arabia
9Pharmacy Techniclnic lll, Pharmaceutical Care Department, King Abdulaziz Medical City Ministry of National Guard, Jeddah, Saudi Arabia
10Pharmacy Techinician III, Pharmaceutical Care Department, King Abdulaziz Medical City Ministry of National Guard, Jeddah, Saudi Arabia
11Pharmacy Techinician II, Pharmaceutical Care Department, King Abdulaziz Medical City Ministry of National Guard, Jeddah, Saudi Arabia
12Pharmacy Techinician III, Pharmaceutical Care Department, King Abdulaziz Medical City Ministry of National Guard, Jeddah, Saudi Arabia

Published
2024-02-04
Issue
Vol 2023 No Issue 4 (2023)
Section
Regular Issue

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