Advanced Drug Formulation Techniques for Targeted Cancer Therapy

Abstract

Targeted cancer therapy has emerged as a transformative approach in oncology, offering selective action against cancer cells while sparing normal tissues. This paper explores advanced drug formulation techniques, including nanoparticle delivery systems, liposomes, dendrimers, and antibody-drug conjugates, that enhance targeted delivery, improve bioavailability, and minimize systemic toxicity. We describe the materials, formulation methods, and outcomes from recent studies, highlighting statistical improvements in drug accumulation in tumor tissues and patient response rates. The integration of nanotechnology and molecular targeting in pharmaceutical formulation marks a critical advancement in personalized cancer therapy.
Recent advancements in molecular pharmacology and targeted nanomedicine have significantly contributed to optimizing drug distribution, overcoming drug resistance mechanisms, and personalizing cancer therapy. Emerging strategies aim not only to localize drug delivery but also to adapt payloads based on tumor genomics, supporting the vision of precision oncology.
In parallel, technological advancements in bioengineering and diagnostic imaging have allowed for better design and monitoring of these drug delivery systems. The integration of stimuli-responsive carriers and ligand-mediated targeting further enhances therapeutic precision, contributing to a paradigm shift from conventional chemotherapy to tailored treatment regimens.