Molecular Docking, In-Vitro Antimicrobial, Antioxidant, and DNA Cleavage Studies of Bis-Coumarin Pyridine Schiff Basemetal Chelates

Abstract

Bis-CoumarinPyridine Schiff basederivative 3(BCPS) metal chelates with hydroxyl functionality on both sides of the coumarin benzene ring of ML.H2O, containing Co (II), Ni (II) and Cu (II) compounds were designed and synthesized by condensation of 2,6-diamino Pyridine and 5-formyl-6-hydroxy coumarin, the compounds are non-electrolytes and are DMSO and DMF soluble. Compounds that were synthesized were characterized using a variety of analytical methods,such as FT-IR, 1H-NMR, 13C-NMR, ESI-MS,and EPR analysis. Coumarins and Schiff bases share an interest in medicinal chemistry because they can have pharmacological effects. Similarly, the target molecules' bio-potency was tested in vitro for antimicrobial (E. coli, S. aureus, P. aeruginosa, and S. typhi) and antifungal (Aspergillus Niger, Aspergillus flavus, and Cladosporium) activity, and the agarose gel electrophoresis technique was used to investigate DNA cleavage, as well as antioxidant properties, which confirmed their promising biological activities when compared to standard drugs.