Immunohistochemical Expression of Cyclin D1 in Invasine Breast Carcinoma and its Correlation with Other Prognostic Parameters

Abstract

Breast carcinoma is one the most common neoplasm in women ranking second among overall cancers in the world. Age, tumour size, histological grade, histological type, lymphovascular invasion, axillary lymph node metastasis and hormone receptor markers are regarded as prognostic markers in patients with breast carcinoma. Cyclin D1 is emerging as a significant biomarker in invasive breast cancer, not still used as a routine prognostic tool in breast cancer, although it has shown its prognostic value in several studies. The recent knowledge in molecular mechanisms of this cancer and consequent targeted treatments have attempted to improve its outcome. Aims of the present study are to assess Cyclin D1 expression in invasive breast carcinoma and to correlate Cyclin D1 expression with other prognostic parameters for invasive breast carcinoma. Patients fulfilling the inclusion criteria and who had undergone mastectomy were selected including both prospective and retrospective cases after obtaining waiver-off consent and clearance from The Institutional Research Committee and Institutional Ethics Committee. The study included 47 cases of Modified radical mastectomies done for various grades and stages of breast carcinoma. Tumour tissues were stained immunohistochemically with Cyclin D1. Semiquantitative scoring was done using Allred score method and its relationship with prognostic parameters was then determined. Cyclin D1 was strong, intermediate, weak/ negative expression in 31.9%, 42.6% and 25.5%.